I've had the same mouse for probably 5 years, and I'm very happy with the result. Unfortunately, the batteries don't make good contact with the pins anymore and sometimes it takes ten minutes of delicate work to get it going again.
So today, I went to buy a mouse, and surprise, surprise, I had forgotten how much it sucks to be a left-handed when purchasing certain objects.
At the computer store, there were about 25 different mouse models, most of them featuring extra buttons, ergononic shape and other cool stuff. I was ready to buy something for even more than 20€ if it was worth it, but due to the non-simmetrical shape of most of them, again I could only go for the cheapest models.
I took a Creative optical mouse, and downgraded from a cordless mouse with 5 buttons + a wheel to a plain simple 3-button + wheel. At least it's USB... all the low end mice are still PS2.
When I was looking for a laptop, one of the requirements was that the touchpad wasn't slightly displaced to the left. So right-handed-ish...
I know there are shops with stuff for left-handed. Once, my mother bought me a pair of nail scissors designed for left-handed people. All that kind of stuff is generally very expensive and anecdotic, though. I wonder if we'll ever see laws that will force manufacturers to provide inverted items on demand. I want one of those cool mice.